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Article

Association between transforming growth factor-beta1 gene C-509T and T869C polymorphisms and rheumatic heart disease.

American heart journal - 1 Jul 2004

Chou Hsiang-Tai, Chen Chien-Hsiun, Tsai Chang-Hai, Tsai Fuu-Jen

Abstract excerpt

BACKGROUND: Scarring and collagen deposition in the valves and destruction of myocytes may result from the combined effects of a smoldering rheumatic process and a constant trauma to the mitral valve or aortic valve by the turbulent flow in rheumatic heart disease (RHD). Transforming growth factor-beta1 (TGF-beta1) may be responsible for the increased valvular fibrosis and calcification in the pathogenesis of...

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Identifiers

PMID: 15215809
DOI: 10.1016/j.ahj.2004.03.032

Genes

RHD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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