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Article

Tumor necrosis factor-alpha 308G>A polymorphism and risk of rheumatic heart disease: a meta-analysis.

Scientific reports - 22 Apr 2014

Zheng Ruo-Long, Zhang Hua, Jiang Wen-Long

Abstract excerpt

Rheumatic heart disease (RHD) remains a serious cardiovascular disorder across the world. Tumor necrosis factor alpha (TNF-α) codifies a potent immunomodulator and pro-inflammatory cytokine that mediates diverse pathological processes. A promoter 308G>A polymorphism in TNF-α has been implicated in RHD risk. However, the results remain controversial. Therefore, to evaluate more precise estimations of the...

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Identifiers

PMID: 24751687
DOI: 10.1038/srep04731
PMCID: PMC3994435

Genes

RHD
TNF

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