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Article

Influence of genetic polymorphisms of IL23R, STAT3, IL12B, and STAT4 on the risk of aplastic anemia and the effect of immunosuppressive therapy.

Annals of hematology - 1 Apr 2018

Zhao Li, Zhu Huanling, Han Bing, Wang Lixin, Sun Yuming, Lu Xiaojun, Huang Chunyan, Tan Bin, Chen Chunxia, Qin Li

Abstract excerpt

Studies have suggested that IL-23/STAT3 and IL-12/STAT4 signaling pathways associate with aplastic anemia (AA) occurrence. Polymorphisms in pathway-related genes may contribute to AA risk. In the current study, we investigated the association between polymorphisms in genes of IL23R, STAT3, IL12B, and STAT4 and occurrence, severity, and immunosuppressive outcome of AA in the Han population in southwest China. In...

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Source

Identifiers

PMID: 29330562
DOI: 10.1007/s00277-018-3227-7

Genes

STAT3
STAT4

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