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Article

Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD.

BMC systems biology - 25 Jun 2014

Chu Jen-hwa, Hersh Craig P, Castaldi Peter J, Cho Michael H, Raby Benjamin A, Laird Nan, Bowler Russell, Rennard Stephen, Loscalzo Joseph, Quackenbush John, Silverman Edwin K

Abstract excerpt

BACKGROUND: The investigation of complex disease heterogeneity has been challenging. Here, we introduce a network-based approach, using partial correlations, that analyzes the relationships among multiple disease-related phenotypes. RESULTS: We applied this method to two large, well-characterized studies of chronic obstructive pulmonary disease (COPD). We also examined the associations between these COPD...

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Identifiers

PMID: 24964944
DOI: 10.1186/1752-0509-8-78
PMCID: PMC4105829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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