Article
Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD.
BMC systems biology - 25 Jun 2014
Chu Jen-hwa, Hersh Craig P, Castaldi Peter J, Cho Michael H, Raby Benjamin A, Laird Nan, Bowler Russell, Rennard Stephen, Loscalzo Joseph, Quackenbush John, Silverman Edwin K
Abstract excerpt
BACKGROUND: The investigation of complex disease heterogeneity has been challenging. Here, we introduce a network-based approach, using partial correlations, that analyzes the relationships among multiple disease-related phenotypes. RESULTS: We applied this method to two large, well-characterized...
Topics
- Case-Control Studies
- Computational Biology
- Humans
- Phenotype
- Polymorphism, Single Nucleotide
- Pulmonary Disease, Chronic Obstructive