Article
Structural characterization of transcription-coupled repair protein UVSSA and its interaction with TFIIH protein.
International journal of biological macromolecules - 30 Aug 2023
Mistry Hiral, Kumari Shweta, Aswal Vinod K, Gupta Gagan D
Abstract excerpt
UV-stimulated scaffold protein A (UVSSA) is a key protein in the Transcription-Coupled Nucleotide Excision Repair (TC-NER) pathway. UVSSA, an intrinsically disordered protein, interacts with multiple members of the pathway, tethering them into the complex. Several studies have reported that UVSSA recruits Transcription Factor IIH (TFIIH) via direct interaction, following which CSB is degraded and the lesion...
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