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Article

PTGS2 polymorphism rs689466 favors breast cancer recurrence in obese patients.

Endocrine-related cancer - 1 Mar 2018

Freitas-Alves Daniely Regina, Vieira-Monteiro Hayra de Andrade, Piranda Diogo Nascimento, Sobral-Leite Marcelo, da Silva Taiana Sousa Lopes, Bergmann Anke, Valença Samuel Santos, Perini Jamila Alessandra, Vianna-Jorge Rosane

Abstract excerpt

Breast cancer is the leading cancer among women, and its increasing incidence is a challenge worldwide. Estrogen exposure is the main risk factor, but obesity among postmenopausal women has been shown to favor disease onset and progression. The link between obesity and mammary carcinogenesis involves elevated estrogen production and proinflammatory stimuli within the adipose tissue, with activation of the...

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Source

Identifiers

PMID: 29321183
DOI: 10.1530/ERC-17-0374

Genes

PTGS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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