Impact of COX2 genotype, ER status and body constitution on risk of early events in different treatment groups of breast cancer patients.

doi:10.1002/ijc.28831

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Article

Impact of COX2 genotype, ER status and body constitution on risk of early events in different treatment groups of breast cancer patients.

International journal of cancer - 15 Oct 2014

Markkula Andrea, Simonsson Maria, Rosendahl Ann H, Gaber Alexander, Ingvar Christian, Rose Carsten, Jernström Helena

Abstract excerpt

The COX2 rs5277 (306G>C) polymorphism has been associated with inflammation-associated cancers. In breast cancer, tumor COX-2 expression has been associated with increased estrogen levels in estrogen receptor (ER)-positive and activated Akt-pathway in ER-negative tumors. Our study investigated the impact of COX2 genotypes on early breast cancer events and treatment response in relation to tumor ER status and body...

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Identifiers

PMID: 24599585
DOI: 10.1002/ijc.28831
PMCID: PMC4225481

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