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Article

Caffeine, creatine, GRIN2A and Parkinson's disease progression.

Journal of the neurological sciences - 15 Apr 2017

Simon David K, Wu Cai, Tilley Barbara C, Lohmann Katja, Klein Christine, Payami Haydeh, Wills Anne-Marie, Aminoff Michael J, Bainbridge Jacquelyn, Dewey Richard, Hauser Robert A, Schaake Susen, Schneider Jay S, Sharma Saloni, Singer Carlos, Tanner Caroline M, Truong Daniel, Wei Peng, Wong Pei Shieen, Yang Tianzhong

Abstract excerpt

Caffeine is neuroprotective in animal models of Parkinson's disease (PD) and caffeine intake is inversely associated with the risk of PD. This association may be influenced by the genotype of GRIN2A, which encodes an NMDA-glutamate-receptor subunit. In two placebo-controlled studies, we detected no association of caffeine intake with the rate of clinical progression of PD, except among subjects taking creatine,...

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Identifiers

PMID: 28320167
DOI: 10.1016/j.jns.2017.02.032
PMCID: PMC5386398

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