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Article

Mutation-induced changes of transmembrane pore size revealed by combined ion-channel conductance and single vesicle permeabilization analyses.

Biochimica et biophysica acta. Biomembranes - 1 May 2018

Largo Eneko, Gladue Douglas P, Torralba Johana, Aguilella Vicente M, Alcaraz Antonio, Borca Manuel V, Nieva José L

Abstract excerpt

Permeabilization of the Endoplasmic Reticulum (ER) is instrumental in the progression of host-cell infection by many viral pathogens. We have described that permeabilization of ER model membranes by the pore-forming domain of the Classical Swine Fever Virus (CSFV) p7 protein depends on two sequence determinants: the C-terminal transmembrane helix, and the preceding polar loop that regulates its activity. Here, by...

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PMID: 29317201
DOI: 10.1016/j.bbamem.2018.01.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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