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Ion channel structure and function of the MERS coronavirus E protein

9 Jul 2025

Abstract excerpt

Coronavirus envelope (E) proteins form drug-targeted ion channels that cause virulence to infected cells. The Middle East respiratory syndrome (MERS) virus has high mortality rates, but its E structure and function are unknown. We report the single-channel conductance and structure of membrane-bound MERS E protein. MERS E conducts K + ions with a unitary conductance of 113 picosiemens, fivefold larger than the...

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PMID: 40632851
DOI: 10.1126/sciadv.adx1788

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