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Identification of potassium and calcium channel inhibitors as modulators of polyomavirus endosomal trafficking

7 May 2020

Abstract excerpt

During virus entry, members of the Polyomaviridae transit the endolysosomal network en route to the endoplasmic reticulum (ER), from which degraded capsids escape into the cytoplasm and enter the nucleus. Emerging evidence suggests that viruses require both endosomal acidification and the correct ionic balance of K+ and Ca2+ ions in endosomes for correct virus trafficking and genome release. Here, using two...

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PMID: 32389733
DOI: 10.1016/j.antiviral.2020.104819

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