Article

Specific determinants of the Transmembrane region of the Andes virus Gc glycoprotein drive the transition from membrane hemifusion to pore formation

2026-03-18

Abstract excerpt

<h4>ABSTRACT</h4> Andes virus (ANDV), a highly pathogenic orthohantavirus, enters host cells through low pH–triggered membrane fusion mediated by the Gc glycoprotein, a class II fusion protein containing a single C-terminal transmembrane domain (TMD). While the ectodomain has been extensively characterized, the role of the TMD in late-stage fusion remains unclear. Here, we investigated the minimal functional leng...

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Literature Corpus work: d7f09617-29c0-5be8-8f1c-7216d125eaec
DOI: 10.64898/2026.03.17.712151

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Specific determinants of the Transmembrane region of the Andes virus Gc glycoprotein drive the transition from membrane hemifusion to pore formationDOI 10.64898/2026.03.17.712151Read

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