Article
Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.
PLoS medicine - 1 Jan 2018
Broce Iris, Karch Celeste M, Wen Natalie, Fan Chun C, Wang Yunpeng, Tan Chin Hong, Kouri Naomi, Ross Owen A, Höglinger Günter U, Muller Ulrich, Hardy John, Momeni Parastoo, Hess Christopher P, Dillon William P, Miller Zachary A, Bonham Luke W, Rabinovici Gil D, Rosen Howard J, Schellenberg Gerard D, Franke Andre, Karlsen Tom H, Veldink Jan H, Ferrari Raffaele, Yokoyama Jennifer S, Miller Bruce L, Andreassen Ole A, Dale Anders M, Desikan Rahul S, Sugrue Leo P
Abstract excerpt
BACKGROUND: Converging evidence suggests that immune-mediated dysfunction plays an important role in the pathogenesis of frontotemporal dementia (FTD). Although genetic studies have shown that immune-associated loci are associated with increased FTD risk, a systematic investigation of genetic overlap between immune-mediated diseases and the spectrum of FTD-related disorders has not been performed. METHODS AND...
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