Back to search

Article

Neuroimmune Transcriptomic Convergence Identifies Druggable Immune Hubs Linking Alzheimer’s Disease and Sjögren’s Syndrome

2026-03-23

Abstract excerpt

<title>Abstract</title> <p>Background Alzheimer's disease (AD) and primary Sjögren's syndrome (pSS) share epidemiological links and neuroimmune features, yet their common molecular signatures remain undefined. We performed an integrative transcriptomic analysis to identify shared differentially expressed genes (DEGs), pathways, regulatory networks, and druggable targets linking systemic autoimmunity to neurodege...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b34161b6-b1f7-5042-bbff-daf49f9ecba5
DOI
10.21203/rs.3.rs-9082632/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Neuroimmune Transcriptomic Convergence Identifies Druggable Immune Hubs Linking Alzheimer’s Disease and Sjögren’s SyndromeDOI 10.21203/rs.3.rs-9082632/v1
Genetic overlap between Alzheimer's disease and immune-mediated diseases: An atlas of shared genetic determinants and biological convergenceSemantic proximity
Integrated Bioinformatic Analysis and Validation Identifies Immune Microenvironment-Related Potential Biomarkers in Alzheimer's DiseaseSemantic proximity
Identification of Significant Immune Related Genes and Pathways in Parkinson’s disease via Bioinformatics Analysis of Single-Cell RNA Sequencing DataSemantic proximity
Transcriptomics explores potential mechanisms for the development of Primary Sjogren’s syndrome to diffuse large B-cell lymphoma in B cellsSemantic proximity
Deciphering the peripheral immune landscape of Alzheimer's disease through integrated multi-omics research and cohort validation.Semantic proximity
Integrated Bioinformatics and Ensemble Learning Reveal Diagnostic Modeling and Drug Discovery in Alzheimer’s DiseaseSemantic proximity
Identification and validation of oxidative stress and immune-related hub genes in Alzheimer’s disease through bioinformatics analysisSemantic proximity
Identification of crosstalk genes and immune characteristics between Alzheimer’s disease and atherosclerosisSemantic proximity
IL-24 and S100A2 as Novel Immune Drivers for Therapeutic Targeting and Precision Subtyping in Atopic DermatitisSemantic proximity
Differential gene expression and immune profiling in Parkinson’s disease: unveiling potential candidate biomarkersSemantic proximity
Exploring shared genes and molecular mechanisms between primary Sjögren's syndrome and pulmonary hypertension based on transcriptome dataSemantic proximity
Genetic overlap between Alzheimer's disease and immune-mediated diseases: an atlas of shared genetic determinants and biological convergence.Semantic proximity
Select a neighboring publication to make it the new centre.