Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases.

doi:10.1136/jnnp-2016-314411

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases.

Journal of neurology, neurosurgery, and psychiatry - 1 Feb 2017

Ferrari Raffaele, Wang Yunpeng, Vandrovcova Jana, Guelfi Sebastian, Witeolar Aree, Karch Celeste M, Schork Andrew J, Fan Chun C, Brewer James B, Momeni Parastoo, Schellenberg Gerard D, Dillon William P, Sugrue Leo P, Hess Christopher P, Yokoyama Jennifer S, Bonham Luke W, Rabinovici Gil D, Miller Bruce L, Andreassen Ole A, Dale Anders M, Hardy John, Desikan Rahul S

Abstract excerpt

BACKGROUND: Clinical, pathological and genetic overlap between sporadic frontotemporal dementia (FTD), Alzheimer's disease (AD) and Parkinson's disease (PD) has been suggested; however, the relationship between these disorders is still not well understood. Here we evaluated genetic overlap between FTD, AD and PD to assess shared pathobiology and identify novel genetic variants associated with increased risk for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alzheimer Disease

Share to Frontotemporal Dementia

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Genotype

Share to Parkinson Disease

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 27899424
DOI: 10.1136/jnnp-2016-314411
PMCID: PMC5237405

Genes

MAPT
APOE
CRHR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases.PMID 27899424Read ↗

Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia.Semantic proximity Read ↗

Shared genetic risk loci between Alzheimer's disease and related dementias, Parkinson's disease, and amyotrophic lateral sclerosis.Semantic proximity Read ↗

Genome-wide analyses reveal shared and distinct genetic architecture linking amyotrophic lateral sclerosis, sporadic frontotemporal dementia and cognitive traitsSemantic proximity Read ↗

Genome Wide Association Study and Next Generation Sequencing: A Glimmer of Light Toward New Possible Horizons in Frontotemporal Dementia ResearchSemantic proximity Read ↗

Shared genetic links between frontotemporal dementia and psychiatric disordersSemantic proximity Read ↗

Frontotemporal dementia and its subtypes: a genome-wide association study.Semantic proximity Read ↗

Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum.Semantic proximity Read ↗

Analysis of genome-wide association studies of Alzheimer disease and of Parkinson disease to determine if these 2 diseases share a common genetic risk.Semantic proximity Read ↗

Genetic risk factor clustering within and across neurodegenerative diseasesSemantic proximity Read ↗

Shared genetic aetiology of Alzheimer’s disease and age-related macular degeneration by APOC1 and APOE genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.