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Article

Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.

JAMA neurology - 1 Jul 2017

Witoelar Aree, Jansen Iris E, Wang Yunpeng, Desikan Rahul S, Gibbs J Raphael, Blauwendraat Cornelis, Thompson Wesley K, Hernandez Dena G, Djurovic Srdjan, Schork Andrew J, Bettella Francesco, Ellinghaus David, Franke Andre, Lie Benedicte A, McEvoy Linda K, Karlsen Tom H, Lesage Suzanne, Morris Huw R, Brice Alexis, Wood Nicholas W, Heutink Peter, Hardy John, Singleton Andrew B, Dale Anders M, Gasser Thomas, Andreassen Ole A, Sharma Manu

Abstract excerpt

Importance: Recent genome-wide association studies (GWAS) and pathway analyses supported long-standing observations of an association between immune-mediated diseases and Parkinson disease (PD). The post-GWAS era provides an opportunity for cross-phenotype analyses between different complex phenotypes. Objectives: To test the hypothesis that there are common genetic risk variants conveying risk of both PD and...

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Source

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Identifiers

PMID: 28586827
DOI: 10.1001/jamaneurol.2017.0469
PMCID: PMC5710535

Genes

MAPT
BOLA2
CRHR1
GAK
TRIM10
WNT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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