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Article

A single-cysteine mutant and chimeras of essential Leishmania Erv can complement the loss of Erv1 but not of Mia40 in yeast.

Redox biology - 1 May 2018

Specht Sandra, Liedgens Linda, Duarte Margarida, Stiegler Alexandra, Wirth Ulrike, Eberhardt Maike, Tomás Ana, Hell Kai, Deponte Marcel

Abstract excerpt

Mia40/CHCHD4 and Erv1/ALR are essential for oxidative protein folding in the mitochondrial intermembrane space of yeast and mammals. In contrast, many protists, including important apicomplexan and kinetoplastid parasites, lack Mia40. Furthermore, the Erv homolog of the model parasite Leishmania tarentolae (LtErv) was shown to be incompatible with Saccharomyces cerevisiae Mia40 (ScMia40). Here we addressed...

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Identifiers

PMID: 29310075
DOI: 10.1016/j.redox.2017.12.010
PMCID: PMC5760468

Genes

CHCHD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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