Article
Mia40 Protein Serves as an Electron Sink in the Mia40-Erv1 Import Pathway.
The Journal of biological chemistry - 21 Aug 2015
Neal Sonya E, Dabir Deepa V, Tienson Heather L, Horn Darryl M, Glaeser Kathrin, Ogozalek Loo Rachel R, Barrientos Antoni, Koehler Carla M
Abstract excerpt
A redox-regulated import pathway consisting of Mia40 and Erv1 mediates the import of cysteine-rich proteins into the mitochondrial intermembrane space. Mia40 is the oxidoreductase that inserts two disulfide bonds into the substrate simultaneously. However, Mia40 has one redox-active cysteine pair, resulting in ambiguity about how Mia40 accepts numerous electrons during substrate oxidation. In this study, we have...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.