Variations of SOST mRNA expression in human bone are associated with DNA polymorphism and DNA methylation in the SOST gene.

doi:10.1016/j.bone.2016.08.004

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Article

Variations of SOST mRNA expression in human bone are associated with DNA polymorphism and DNA methylation in the SOST gene.

Bone - 1 Nov 2016

Lhaneche Leila, Hald Jannie D, Domingues Aline, Hannouche Didier, Delepine Marc, Zelenika Diana, Boland Anne, Ostertag Agnes, Cohen-Solal Martine, Langdahl Bente L, Harsløf Torben, de Vernejoul Marie-Christine, Geoffroy Valérie, Jehan Frédéric

Abstract excerpt

SOST encodes sclerostin, an inhibitor of bone formation that antagonizes canonical Wnt signaling. Variations of SOST expression have an impact on bone mineral density (BMD) and bone strength. We hypothesized that genetic and epigenetic DNA modifications have an impact on SOST gene expression. By analyzing 43 bone samples from women, we found that rs851054 (G/A) is associated with SOST mRNA expression, donors with...

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Identifiers

PMID: 27519970
DOI: 10.1016/j.bone.2016.08.004

Genes

SOST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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