Methylation of bone SOST, its mRNA, and serum sclerostin levels correlate strongly with fracture risk in postmenopausal women.

doi:10.1002/jbmr.2342

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Article

Methylation of bone SOST, its mRNA, and serum sclerostin levels correlate strongly with fracture risk in postmenopausal women.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 2015

Reppe Sjur, Noer Agate, Grimholt Runa M, Halldórsson Bjarni V, Medina-Gomez Carolina, Gautvik Vigdis T, Olstad Ole Kristoffer, Berg Jens Petter, Datta Harish, Estrada Karol, Hofman Albert, Uitterlinden André G, Rivadeneira Fernando, Lyle Robert, Collas Philippe, Gautvik Kaare M

Abstract excerpt

Inhibition of sclerostin, a glycoprotein secreted by osteocytes, offers a new therapeutic paradigm for treatment of osteoporosis (OP) through its critical role as Wnt/catenin signaling regulator. This study describes the epigenetic regulation of SOST expression in bone biopsies of postmenopausal women. We correlated serum sclerostin to bone mineral density (BMD), fractures, and bone remodeling parameters, and...

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PMID: 25155887
DOI: 10.1002/jbmr.2342

Genes

SOST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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