Article
Relationship of sclerostin and secreted frizzled protein polymorphisms with bone mineral density: an association study with replication in postmenopausal women.
Menopause (New York, N.Y.) - 1 Jul 2011
Valero Carmen, Zarrabeitia María T, Hernández José L, Pineda Begoña, Cano Antonio, García-Pérez Miguel A, Riancho José A
Abstract excerpt
OBJECTIVE: Secreted frizzled-related protein and sclerostin, encoded by FRZB and SOST genes, respectively, are extracellular Wnt inhibitors that tend to decrease bone formation. The purpose of this study was to explore the association of the sets of polymorphisms capturing common variations of these genes with bone mineral density (BMD). METHODS: Twelve polymorphic loci of the FRZB gene and 7 of the SOST gene...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.