Article
Genotyping Single Nucleotide Polymorphisms and Copy Number Variability of the FCGRs Expressed on NK Cells.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016
Erbe Amy K, Wang Wei, Gallenberger Mikayla, Hank Jacquelyn A, Sondel Paul M
Abstract excerpt
Natural killer (NK) cells are one of the main effector immune cells involved in antibody-dependent cell-mediated cytotoxicity (ADCC). Upon recognition of cell-bound IgG antibodies, which occurs through Fc gamma receptors (FCGRs) expressed on the cell surface of NK cells, NK cells become activated and lyse target tumor or infected cells. The FCGRs, FCGR3A and FCGR2C, expressed on the surface of NK cells have...
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