Article
Heme oxygenase-1 genetic variants and the conundrum of hyperbilirubinemia in African-American newborns.
Journal of perinatology : official journal of the California Perinatal Association - 1 Apr 2018
Schutzman David L, Gatien Erica, Ajayi Samuel, Wong Ronald J
Abstract excerpt
BACKGROUND: African-American (AA) infants are known to have, overall, lower bilirubin levels than infants of other ethnicities during their birth hospitalization. However, they are known to have a higher incidence of severe hyperbilirubinemia and are over represented in the US Kernicterus Registry. Heme oxygenase-1 (HO) is the rate limiting enzyme in heme metabolism leading to the equimolar production of...
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