Article
UGT1A1 gene polymorphisms in North Indian neonates presenting with unconjugated hyperbilirubinemia.
Pediatric research - 1 Jun 2009
Agrawal Sunil K, Kumar Praveen, Rathi Ritu, Sharma Neeraj, DAS Reena, Prasad Rajendra, Narang Anil
Abstract excerpt
Genetic factors are implicated in pathogenesis of neonatal hyperbilirubinemia. In this nested case-control study, we determined 1) frequency of thymine-adenine (TA)n promoter polymorphism and Gly71Arg mutation in uridine diphosphoglucuronate-glucuronosyltransferase 1A1 (UGT1A1) gene in neonates > or =35-wk gestation presenting with bilirubin levels > or =18 mg/dL and controls, 2) interaction among (TA)n promoter...
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