Article
Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism?
Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 1998
Beutler E, Gelbart T, Demina A
Abstract excerpt
A polymorphism in the promoter of the UDP-glucuronosyltransferase 1 (UGT1A1) gene has been shown to cause Gilbert syndrome, a benign form of unconjugated bilirubinemia. Promoters containing seven thymine adenine (ta) repeats have been found to be less active than the wild-type six repeats, and th...
Topics
- Bilirubin
- Gene Expression Regulation, Enzymologic
- Genetic Variation
- Glucuronosyltransferase
- Humans
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Racial Groups