An Expanded Role for the RFX Transcription Factor DAF-19, with Dual Functions in Ciliated and Nonciliated Neurons.

doi:10.1534/genetics.117.300571

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An Expanded Role for the RFX Transcription Factor DAF-19, with Dual Functions in Ciliated and Nonciliated Neurons.

Genetics - 1 Mar 2018

De Stasio Elizabeth A, Mueller Katherine P, Bauer Rosemary J, Hurlburt Alexander J, Bice Sophie A, Scholtz Sophie L, Phirke Prasad, Sugiaman-Trapman Debora, Stinson Loraina A, Olson Haili B, Vogel Savannah L, Ek-Vazquez Zabdiel, Esemen Yagmur, Korzynski Jessica, Wolfe Kelsey, Arbuckle Bonnie N, Zhang He, Lombard-Knapp Gaelen, Piasecki Brian P, Swoboda Peter

Abstract excerpt

Regulatory Factor X (RFX) transcription factors (TFs) are best known for activating genes required for ciliogenesis in both vertebrates and invertebrates. In humans, eight RFX TFs have a variety of tissue-specific functions, while in the worm Caenorhabditis elegans, the sole RFX gene, daf-19, encodes a set of nested isoforms. Null alleles of daf-19 confer pleiotropic effects including altered development with a...

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PMID: 29301909
DOI: 10.1534/genetics.117.300571
PMCID: PMC5844324

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