Article
Transcriptional profiling of C. elegans DAF-19 uncovers a ciliary base-associated protein and a CDK/CCRK/LF2p-related kinase required for intraflagellar transport.
Developmental biology - 1 Sept 2011
Phirke Prasad, Efimenko Evgeni, Mohan Swetha, Burghoorn Jan, Crona Filip, Bakhoum Mathieu W, Trieb Maria, Schuske Kim, Jorgensen Erik M, Piasecki Brian P, Leroux Michel R, Swoboda Peter
Abstract excerpt
Cilia are ubiquitous cell surface projections that mediate various sensory- and motility-based processes and are implicated in a growing number of multi-organ genetic disorders termed ciliopathies. To identify new components required for cilium biogenesis and function, we sought to further define and validate the transcriptional targets of DAF-19, the ciliogenic C. elegans RFX transcription factor....
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