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Article

The role of SMAD3 in the genetic predisposition to papillary thyroid carcinoma.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Sept 2018

Wang Yanqiang, He Huiling, Liyanarachchi Sandya, Genutis Luke K, Li Wei, Yu Lianbo, Phay John E, Shen Rulong, Brock Pamela, de la Chapelle Albert

Abstract excerpt

PURPOSE: To identify and characterize the functional variants, regulatory gene networks, and potential binding targets of SMAD3 in the 15q22 thyroid cancer risk locus. METHODS: We performed linkage disequilibrium (LD) and haplotype analyses to fine map the 15q22 locus. Luciferase reporter assays were applied to evaluate the regulatory effects of the candidate variants. Knockdown by small interfering RNA,...

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Topics

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Share to Thyroid Cancer, Papillary
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Immunoprecipitation

Share to Chromosomes, Human, Pair 15

Share to Linkage Disequilibrium

Share to Promoter Regions, Genetic

Share to Smad3 Protein

Share to Thyroid Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 29300379
DOI: 10.1038/gim.2017.224
PMCID: PMC6030507

Genes

SMAD3
SPRY4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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