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Article

Genetic predisposition to papillary thyroid carcinoma: involvement of FOXE1, TSHR, and a novel lincRNA gene, PTCSC2.

The Journal of clinical endocrinology and metabolism - 1 Jan 2015

He Huiling, Li Wei, Liyanarachchi Sandya, Jendrzejewski Jaroslaw, Srinivas Mukund, Davuluri Ramana V, Nagy Rebecca, de la Chapelle Albert

Abstract excerpt

CONTEXT: By genome-wide association studies, the risk allele [A] of SNP rs965513 predisposes strongly to papillary thyroid carcinoma (PTC). It is located in a gene-poor region of 9q22, some 60 kb from the FOXE1 gene. The underlying mechanisms remain to be discovered. OBJECTIVE: Our objective was to identify novel transcripts in the 9q22 locus and correlate gene expression levels with the genotypes of rs965513....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Carcinoma, Papillary
Share to Forkhead Transcription Factors
Share to Genome-Wide Association Study
Share to Polymorphism, Single Nucleotide
Share to Receptors, Thyrotropin
Share to RNA, Long Noncoding
Share to Thyroid Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 25303483
DOI: 10.1210/jc.2014-2147
PMCID: PMC4283026

Genes

FOXE1
TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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