Article
The Role of NRG1 in the Predisposition to Papillary Thyroid Carcinoma.
The Journal of clinical endocrinology and metabolism - 1 Apr 2018
He Huiling, Li Wei, Liyanarachchi Sandya, Wang Yanqiang, Yu Lianbo, Genutis Luke K, Maharry Sophia, Phay John E, Shen Rulong, Brock Pamela, de la Chapelle Albert
Abstract excerpt
Context: Previous genome-wide association studies have shown that single-nucleotide polymorphism (SNP) rs2439302 in chromosome 8p12 is significantly associated with papillary thyroid carcinoma (PTC) risk and dysregulated NRG1 expression. The underlying mechanisms remain to be discovered. Objective: To evaluate the expression of NRG1 isoforms, candidate functional variants, and potential genes downstream of NRG1...
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