Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation and cytoprotective role of hexokinase III.

PloS one - 3 Nov 2010

Wyatt Eugene, Wu Rongxue, Rabeh Wael, Park Hee-Won, Ghanefar Mohsen, Ardehali Hossein

Abstract excerpt

BACKGROUND: Hexokinases (HKs) catalyze the first step in glucose metabolism. Of the three mammalian 100-kDa HK isoforms, HKI and II can bind to mitochondria and protect against cell death. HKIII does not bind mitochondria, and little is known about its regulation or cytoprotective effects. We stu...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Hypoxia
Share to Cytoprotection
Share to Hexokinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrogen Peroxide

Share to Hypoxia-Inducible Factor 1

Share to Membrane Potential, Mitochondrial

Share to Microscopy, Confocal

Share to Oxidants

Source

Open in PubMed Open full text

Identifiers

PMID: 21072205
DOI: 10.1371/journal.pone.0013823
PMCID: PMC2972215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21072205-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation and cytoprotective role of hexokinase III.PMID 21072205Read ↗

Unlocking the Potential of HK2 in Cancer Metabolism and TherapeuticsSemantic proximity Read ↗

Hexokinase: gene structure and mutations.Semantic proximity Read ↗

p63 supports aerobic respiration through hexokinase II.Semantic proximity Read ↗

Hexokinase domain-containing protein-1 in metabolic diseases and beyondSemantic proximity Read ↗

The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation.Semantic proximity Read ↗

Hexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibition.Semantic proximity Read ↗

Hexokinases in cancer and other pathologiesSemantic proximity Read ↗

Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP productionSemantic proximity Read ↗

Molecular characterization of six new cases of red blood cell hexokinase deficiency yields four novel mutations in HK1.Semantic proximity Read ↗

Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions.Semantic proximity Read ↗

Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention.Semantic proximity Read ↗

Hexokinase 1 blocks apoptotic signals at the mitochondriaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.