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Article

Structural Basis of pH Dependence of Neoculin, a Sweet Taste-Modifying Protein.

PloS one - 1 Jan 2015

Ohkubo Takayuki, Tamiya Minoru, Abe Keiko, Ishiguro Masaji

Abstract excerpt

Among proteins utilized as sweeteners, neoculin and miraculin are taste-modifying proteins that exhibit pH-dependent sweetness. Several experiments on neoculin have shown that His11 of neoculin is responsible for pH dependence. We investigated the molecular mechanism of the pH dependence of neoculin by molecular dynamics (MD) calculations. The MD calculations for the dimeric structures of neoculin and His11...

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Identifiers

PMID: 26010443
DOI: 10.1371/journal.pone.0126921
PMCID: PMC4444330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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