Article
Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.
Neurology - 23 Jan 2018
McCormack Mark, Gui Hongsheng, Ingason Andrés, Speed Doug, Wright Galen E B, Zhang Eunice J, Secolin Rodrigo, Yasuda Clarissa, Kwok Maxwell, Wolking Stefan, Becker Felicitas, Rau Sarah, Avbersek Andreja, Heggeli Kristin, Leu Costin, Depondt Chantal, Sills Graeme J, Marson Anthony G, Auce Pauls, Brodie Martin J, Francis Ben, Johnson Michael R, Koeleman Bobby P C, Striano Pasquale, Coppola Antonietta, Zara Federico, Kunz Wolfram S, Sander Josemir W, Lerche Holger, Klein Karl Martin, Weckhuysen Sarah, Krenn Martin, Gudmundsson Lárus J, Stefánsson Kári, Krause Roland, Shear Neil, Ross Colin J D, Delanty Norman, Pirmohamed Munir, Carleton Bruce C, Cendes Fernando, Lopes-Cendes Iscia, Liao Wei-Ping, O'Brien Terence J, Sisodiya Sanjay M, Cherny Stacey, Kwan Patrick, Baum Larry, Cavalleri Gianpiero L
Abstract excerpt
OBJECTIVE: To characterize, among European and Han Chinese populations, the genetic predictors of maculopapular exanthema (MPE), a cutaneous adverse drug reaction common to antiepileptic drugs. METHODS: We conducted a case-control genome-wide association study of autosomal genotypes, including Class I and II human leukocyte antigen (HLA) alleles, in 323 cases and 1,321 drug-tolerant controls from epilepsy cohorts...
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