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Article

Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions.

Pharmacogenomics - 1 Mar 2012

McCormack Mark, Urban Thomas J, Shianna Kevin V, Walley Nicole, Pandolfo Massimo, Depondt Chantal, Chaila Elijah, O'Conner Gerard D, Kasperavičiūtė Dalia, Radtke Rodney A, Heinzen Erin L, Sisodiya Sanjay M, Delanty Norman, Cavalleri Gianpiero L

Abstract excerpt

AIMS: An association between carbamazepine-induced hypersensitivity and HLA-A*3101 has been reported in populations of both European and Asian descent. We aimed to investigate HLA-A*3101 and other common variants across the genome as markers for cutaneous adverse drug reactions (cADRs) attributed to lamotrigine and phenytoin. MATERIALS & METHODS: We recruited patients with lamotrigine-induced cADRs (n = 46) and...

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Identifiers

PMID: 22379998
DOI: 10.2217/pgs.11.165
PMCID: PMC3428903

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