Article
Genetic polymorphism and decreased expression of HLA class II DP genes are associated with HBV reactivation in patients treated with immunomodulatory agents.
Journal of medical virology - 1 Apr 2018
Matsuda Hidetaka, Hiramatsu Katsushi, Akazawa Yu, Nosaka Takuto, Saito Yasushi, Ozaki Yoshihiko, Hayama Ryoko, Takahashi Kazuto, Naito Tatsushi, Ofuji Kazuya, Ohtani Masahiro, Nemoto Tomoyuki, Hida Yukio, Kimura Hideki, Soya Yoshihiro, Nakamoto Yasunari
Abstract excerpt
Hepatitis B virus (HBV) reactivation can be triggered by immunosuppressive chemotherapy. HLA class II molecules may play a role in HBV reactivation. Genetic polymorphism and mRNA expression of HLA class II were examined in patients with latent HBV infection treated with immunosuppressive therapies. Subjects with resolved HBV infection who had undergone treatment with immunosuppressive chemotherapies were...
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