Article
Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors.
Nature immunology - 1 Mar 2018
Patin Etienne, Hasan Milena, Bergstedt Jacob, Rouilly Vincent, Libri Valentina, Urrutia Alejandra, Alanio Cécile, Scepanovic Petar, Hammer Christian, Jönsson Friederike, Beitz Benoît, Quach Hélène, Lim Yoong Wearn, Hunkapiller Julie, Zepeda Magge, Green Cherie, Piasecka Barbara, Leloup Claire, Rogge Lars, Huetz François, Peguillet Isabelle, Lantz Olivier, Fontes Magnus, Di Santo James P, Thomas Stéphanie, Fellay Jacques, Duffy Darragh, Quintana-Murci Lluís, Albert Matthew L
Abstract excerpt
The quantification and characterization of circulating immune cells provide key indicators of human health and disease. To identify the relative effects of environmental and genetic factors on variation in the parameters of innate and adaptive immune cells in homeostatic conditions, we combined standardized flow cytometry of blood leukocytes and genome-wide DNA genotyping of 1,000 healthy, unrelated people of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.