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Article

Characterization of Allele-Specific Regulation of Telomerase Reverse Transcriptase in Promoter Mutant Thyroid Cancer Cell Lines.

Thyroid : official journal of the American Thyroid Association - 1 Oct 2020

McKelvey Brittany A, Gilpatrick Timothy, Wang Yongchun, Timp Winston, Umbricht Christopher B, Zeiger Martha A

Abstract excerpt

Background: Telomerase reverse transcriptase (TERT) promoter mutations play a role in carcinogenesis and are found in both tumors and cancer cell lines. TERT promoter methylation, transcription factor binding, chromatin remodeling, and alternative splicing are also known to play an integral role in TERT regulation. Methods: Using nanopore Cas9 targeted sequencing, we characterized allele-specific methylation in...

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Identifiers

PMID: 32228178
DOI: 10.1089/thy.2020.0055
PMCID: PMC7583328

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