Article
Transmissible Mycobacterium tuberculosis Strains Share Genetic Markers and Immune Phenotypes.
American journal of respiratory and critical care medicine - 1 Jun 2017
Nebenzahl-Guimaraes Hanna, van Laarhoven Arjan, Farhat Maha R, Koeken Valerie A C M, Mandemakers Jornt J, Zomer Aldert, van Hijum Sacha A F T, Netea Mihai G, Murray Megan, van Crevel Reinout, van Soolingen Dick
Abstract excerpt
RATIONALE: Successful transmission of tuberculosis depends on the interplay of human behavior, host immune responses, and Mycobacterium tuberculosis virulence factors. Previous studies have been focused on identifying host risk factors associated with increased transmission, but the contribution of specific genetic variations in mycobacterial strains themselves are still unknown. OBJECTIVES: To identify...
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