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Article

Integrative genome and transcriptome analyses reveal two distinct types of ring chromosome in soft tissue sarcomas.

Human molecular genetics - 15 Feb 2014

Nord Karolin H, Macchia Gemma, Tayebwa Johnbosco, Nilsson Jenny, Vult von Steyern Fredrik, Brosjö Otte, Mandahl Nils, Mertens Fredrik

Abstract excerpt

Gene amplification is a common phenomenon in malignant neoplasms of all types. One mechanism behind increased gene copy number is the formation of ring chromosomes. Such structures are mitotically unstable and during tumor progression they accumulate material from many different parts of the geno...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24070870
DOI: 10.1093/hmg/ddt479

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24070870-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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