Haplotypes composed of minor frequency single nucleotide polymorphisms of the TNF gene protect from progression into sepsis: A study using the new sepsis classification.

doi:10.1016/j.ijid.2017.12.008

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Article

Haplotypes composed of minor frequency single nucleotide polymorphisms of the TNF gene protect from progression into sepsis: A study using the new sepsis classification.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Feb 2018

Retsas Theodoros, Huse Klaus, Lazaridis Lazaros-Dimitrios, Karampela Niki, Bauer Michael, Platzer Matthias, Kolonia Virginia, Papageorgiou Eirini, Giamarellos-Bourboulis Evangelos J, Dimopoulos George

Abstract excerpt

OBJECTIVES: Several articles have provided conflicting results regarding the role of single nucleotide polymorphisms (SNPs) in the promoter region of the TNF gene in susceptibility to sepsis. Former articles have been based on previous definitions of sepsis. This study investigated the influence of TNF haplotypes on the development of sepsis using the new Sepsis-3 definitions. METHODS: DNA was isolated from...

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PMID: 29274398
DOI: 10.1016/j.ijid.2017.12.008

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