Article
Absence of BRAFV600E mutation in odontogenic keratocysts.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Feb 2018
França Josiane Alves, de Sousa Sílvia Ferreira, Diniz Marina Gonçalves, Pereira Thaís Dos Santos Fontes, de Resende Taynara Asevedo Campos, Santos Jean Nunes Dos, Gomez Ricardo Santiago, Gomes Carolina Cavalieri
Abstract excerpt
BACKGROUND: Mutations in the patched 1 (PTCH1) gene are the main genetic alteration reported in sporadic and nevoid basal cell carcinoma-associated odontogenic keratocyst (OKC). Oncogenic mutations, including BRAFV600E, previously considered exclusive of malignant neoplasms have been reported in odontogenic tumors. Recently, a high frequency of BRAFV600E mutation has been reported in OKC. Because of the...
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