Article
The BRAF p.V600E mutation is a common event in ameloblastomas but is absent in odontogenic keratocysts.
Oral surgery, oral medicine, oral pathology and oral radiology - 1 Mar 2020
Zhang Ran, Yang Qiaolin, Qu Jiafei, Hong Yingying, Liu Peng, Li Tiejun
Abstract excerpt
OBJECTIVE: Odontogenic keratocysts (OKCs) are jaw lesions with a tendency to recur. PTCH1 gene mutations are common events in most OKCs; however, other genetic alterations underlying OKC pathogenesis have not yet been elucidated. BRAF p.V600E mutations have recently been detected in some odontogenic tumors, such as ameloblastoma and ameloblastic fibroma, although their involvement in OKC is still unclear. In this...
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