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Article

Underestimated PTCH1 mutation rate in sporadic keratocystic odontogenic tumors.

Oral oncology - 1 Jan 2015

Qu Jiafei, Yu Feiyan, Hong Yingying, Guo Yanyan, Sun Lisha, Li Xuefen, Zhang Jianyun, Zhang Heyu, Shi Ruirui, Chen Feng, Li Tiejun

Abstract excerpt

OBJECTIVES: Keratocystic odontogenic tumors (KCOTs) are benign cystic lesions of the jaws that occur sporadically in isolation or in association with nevoid basal cell carcinoma syndrome (NBCCS). The protein patched homolog 1 gene (PTCH1) is associated with NBCCS development and tumor genesis associated with this syndrome. However, previous studies have revealed that more than 85% of syndromic KCOTs and less than...

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Identifiers

PMID: 25458233
DOI: 10.1016/j.oraloncology.2014.09.016

Genes

PTCH1

Provenance

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