Article
Novel PTCH1 mutations in patients with keratocystic odontogenic tumors screened for nevoid basal cell carcinoma (NBCC) syndrome.
PloS one - 1 Jan 2012
Pastorino Lorenza, Pollio Annamaria, Pellacani Giovanni, Guarneri Carmelo, Ghiorzo Paola, Longo Caterina, Bruno William, Giusti Francesca, Bassoli Sara, Bianchi-Scarrà Giovanna, Ruini Cristel, Seidenari Stefania, Tomasi Aldo, Ponti Giovanni
Abstract excerpt
Keratocystic odontogenic tumors (KCOTs) are cystic tumors that arise sporadically or associated with nevoid basal cell carcinoma syndrome (NBCCS). NBCCS is a rare autosomal dominantly inherited disease mainly characterized by multiple basal cell carcinomas, KCOTs of the jaws and a variety of other tumors. PTCH1 mutation can be found both in sporadic or NBCCS associated KCOTs. The aim of the current study was to...
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