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Article

LGR5 promotes cancer stem cell traits and chemoresistance in cervical cancer

7 Sept 2017

Abstract excerpt

Abstract Cancer stem cells (CSCs), also known as tumor-initiating cells, contribute to tumorigenesis, resistance to chemoradiotherapy and recurrence in human cancers, suggesting targeting CSCs may represent a potential therapeutic strategy. Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) has recently been found to be a bona fide marker of colorectal CSCs. Our previous study showed that LGR5...

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PMID: 28880275
DOI: 10.1038/cddis.2017.393

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