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Article

Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2.

Stem cells (Dayton, Ohio) - 1 Sept 2013

Wang Ying, Dong Jie, Li Dali, Lai Li, Siwko Stefan, Li Yi, Liu Mingyao

Abstract excerpt

The key signaling networks regulating mammary stem cells are poorly defined. The leucine-rich repeat containing G protein-coupled receptor (Lgr) family has been implicated in intestinal, gastric, and epidermal stem cell functions. We investigated whether Lgr4 functions in mammary gland development and mammary stem cells. We found that Lgr4(-/-) mice had delayed ductal development, fewer terminal end buds, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23712846
DOI: 10.1002/stem.1438
PMCID: PMC3934111

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