Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LRP5 promotes cancer stem cell traits and chemoresistance in colorectal cancer.

Journal of cellular and molecular medicine - 1 Feb 2022

Nie Xiaobo, Liu Huiyang, Ye Wenling, Wei Xiaoyun, Fan Lili, Ma Han, Li Lanqing, Xue Wanting, Qi Wenting, Wang Yan-Dong, Chen Wei-Dong

Abstract excerpt

The overactivation of canonical Wnt/β-catenin pathway and the maintenance of cancer stem cells (CSCs) are essential for the onset and malignant progression of most human cancers. However, their regulatory mechanism in colorectal cancer (CRC) has not yet been well demonstrated. Low-density lipoprotein receptor-related protein 5 (LRP5) has been identified as an indispensable co-receptor with frizzled family members...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Drug Resistance, Neoplasm

Share to Low Density Lipoprotein Receptor-Related Protein-5

Share to Neoplastic Stem Cells

Share to Phenotype

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 34997691
DOI: 10.1111/jcmm.17164
PMCID: PMC8831954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LRP5 promotes cancer stem cell traits and chemoresistance in colorectal cancer.PMID 34997691Read ↗

Lgr5 in cancer biology: functional identification of Lgr5 in cancer progression and potential opportunities for novel therapySemantic proximity Read ↗

The Expression of Stem Cell Marker LGR5 and Its Coexpression with Β-Catenin in Sporadic Colorectal Carcinoma and Adenoma: A Comparative Immunohistochemical StudySemantic proximity Read ↗

Co-expression of Lgr5 and CXCR4 characterizes cancer stem-like cells of colorectal cancer.Semantic proximity Read ↗

LGR5 promotes cancer stem cell traits and chemoresistance in cervical cancerSemantic proximity Read ↗

Clinical Importance of Wnt5a in the Pathogenesis of Colorectal CancerSemantic proximity Read ↗

Lgr5 is a potential marker of colorectal carcinoma stem cells that correlates with patient survivalSemantic proximity Read ↗

The intestinal stem cell as a target: A reviewSemantic proximity Read ↗

Lgr5+CD44+EpCAM+ Strictly Defines Cancer Stem Cells in Human Colorectal CancerSemantic proximity Read ↗

Colorectal Cancer Stem Cell Biomarkers: Biological Traits and Prognostic InsightsSemantic proximity Read ↗

LGR5 Is a Negative Regulator of Tumourigenicity, Antagonizes Wnt Signalling and Regulates Cell Adhesion in Colorectal Cancer Cell LinesSemantic proximity Read ↗

FZD5 contributes to TNBC proliferation, DNA damage repair and stemness.Semantic proximity Read ↗

ITGB5 is a prognostic factor in colorectal cancer and promotes cancer progression and metastasis through the Wnt signaling pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.