HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model.

doi:10.1016/j.ebiom.2017.12.011

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Article

HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model.

EBioMedicine - 1 Jan 2018

Melo Esther, Oertle Philipp, Trepp Carolyn, Meistermann Hélène, Burgoyne Thomas, Sborgi Lorenzo, Cabrera Alvaro Cortes, Chen Chia-Yi, Hoflack Jean-Christophe, Kam-Thong Tony, Schmucki Roland, Badi Laura, Flint Nicholas, Ghiani Zeynep Eren, Delobel Fréderic, Stucki Corinne, Gromo Giulia, Einhaus Alfred, Hornsperger Benoit, Golling Sabrina, Siebourg-Polster Juliane, Gerber Francoise, Bohrmann Bernd, Futter Clare, Dunkley Tom, Hiller Sebastian, Schilling Oliver, Enzmann Volker, Fauser Sascha, Plodinec Marija, Iacone Roberto

Abstract excerpt

Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss. The protein HtrA1 is enriched in retinal pigment epithelial (RPE) cells isolated from AMD patients and in drusen deposits. However, it is poorly understood how increased levels of HtrA1 affect the physiological function of the RPE at the intracellular level. Here, we developed hfRPE (human fetal retinal pigment epithelial)...

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PMID: 29269042
DOI: 10.1016/j.ebiom.2017.12.011
PMCID: PMC5828370

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