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Article

Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration.

Cell stem cell - 4 May 2017

Saini Janmeet S, Corneo Barbara, Miller Justine D, Kiehl Thomas R, Wang Qingjie, Boles Nathan C, Blenkinsop Timothy A, Stern Jeffrey H, Temple Sally

Abstract excerpt

Age-related macular degeneration (AMD) affects the retinal pigment epithelium (RPE), a cell monolayer essential for photoreceptor survival, and is the leading cause of vision loss in the elderly. There are no disease-altering therapies for dry AMD, which is characterized by accumulation of subretinal drusen deposits and complement-driven inflammation. We report the derivation of human-induced pluripotent stem...

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Share to Induced Pluripotent Stem Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28132833
DOI: 10.1016/j.stem.2016.12.015
PMCID: PMC5419856

Genes

ARMS2
HTRA1
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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