Article
Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells.
Molecular vision - 1 Jan 2017
Samuel William, Jaworski Cynthia, Postnikova Olga A, Kutty R Krishnan, Duncan Todd, Tan Li Xuan, Poliakov Eugenia, Lakkaraju Aparna, Redmond T Michael
Abstract excerpt
PURPOSE: The RPE cell line ARPE-19 provides a dependable and widely used alternative to native RPE. However, replication of the native RPE phenotype becomes more difficult because these cells lose their specialized phenotype after multiple passages. Compounding this problem is the widespread use of ARPE-19 cells in an undifferentiated state to attempt to model RPE functions. We wished to determine whether...
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